Scientists from University of California-Berkeley and Broad Institute invent a way to use Crispr-Cas9 for gene editing and how to apply it to mammals.
August 2013
Scientists use Crispr to alter the genes of rice.
It’s the first plant proven amenable to this gene editing approach.
January 2014
The first monkeys with customized mutations are born.
The first case that uses Crispr-Cas9 with primates, it’s a promising step toward using gene-editing for human diseases.
July 2014
The first paper shows how to use Crispr to make a gene drive, a system that guarantees inheritance of a particular gene by all offspring.
September 2014
This is the first time Crispr has been successfully delivered throughout the body to treat grown animals with a genetic disease.
March 2015
Unknown risks need to be assessed before technology proceeds.
April 2015
First use of Crispr in “non-viable” human embryos, which don’t have a chance of becoming full-grown humans.
September 2015
Chinese scientists edit the genes of two goats to make them ultra-hairy.
Extra-hairy goats produce more cashmere than normal goats.
October 2015
Chinese scientists edit out genes in beagles and roughly doubled the dogs’ muscle sizes.
The idea is to make them better policy and military dogs.
June 2016
Target Malaria, a project by the Gates Foundation, begins development of a gene drive to eliminate malaria mosquitoes.
August 2016
United States Department of Agriculture confirms that Crispr-edited anti-browning mushroom would not be subject to USDA approval.
Gene-edited crops are not GMOs as long as they don’t introduce foreign genes.
December 2016
Scientists from Sichuan University in China use Crispr-edited cells to help a patient fight metastatic lung cancer.
This is the first time Crispr is used in a live human body.
January 2017
The US Food and Drug Administration (FDA) releases a draft rule that treats edited DNA as a drug, subjecting gene-edited animals to regulatory requirements.
Animals aren’t treated by the FDA in the the same way as plants.
May 2017
Scientists develop jointless tomatoes with fewer branches.
These tomatoes wouldn’t tangle with one another, thus increasing yields.
July 2017
Rejuvenate Bio tests gene therapy on four beagles.
The company is marketing Crispr as a tool to increase the lifespan of pets.
September 2017
Egenesis develops retrovirus-free pigs that can be used as organ donors for people.
March 2018
The USDA announced that it will not regulate crops that have been genetically edited, as long as the editing process does not introduce foreign genes to the species.
The federal agency confirms its stance in an official announcement.
May 2018
Scientists use Crispr to develop a rice plant that produces 25%-31% more grain in a field test.
August 2018
Chinese scientists for the first time do base editing on viable human embryos.
September 2018
London scientists announce their gene drive successfully wiped out an entire lab population of mosquitoes in eight generations.
It will take another five to 10 years to bring the technology to the market.
November 2018
The first clinical trial of Crispr in humans begins in Europe. Twelve patients with blood disorders enroll.
This is a real test for medical applications of the technology in one of the biggest markets.
November 2018
A Chinese scientist announces the existence of twin girls whose genes he edited to make them immune to AIDS.
This is the first time known scientists used CRISPR to edit human embryos resulting in a live birth.